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Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer

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Eckstein, Markus ; Kimmel, Charlotte ; Bruendl, Johannes ; Weber, Florian ; Denzinger, Stefan ; Gierth, Michael ; Burger, Maximilian ; Hartmann, Arndt ; Otto, Wolfgang ; Breyer, Johannes
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2022 13:12


Tumor budding is defined as a single cell or a cluster of up to 5 tumor cells at the invasion front. Due to the difficulty of identifying patients at high risk for pT1 non-muscle-invasive bladder cancer (NMIBC) and the difficulties in T1 substaging, tumor budding was evaluated as a potential alternative and prognostic parameter in these patients. Tumor budding as well as growth pattern, invasion ...


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