Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-514012
DOI to cite this document:: 10.5283/epub.51401

Eckstein, Markus ; Kimmel, Charlotte ; Bruendl, Johannes ; Weber, Florian ; Denzinger, Stefan ; Gierth, Michael ; Burger, Maximilian ; Hartmann, Arndt ; Otto, Wolfgang ; Breyer, Johannes

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Date of publication of this fulltext: 12 Jan 2022 13:12

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Abstract

Tumor budding is defined as a single cell or a cluster of up to 5 tumor cells at the invasion front. Due to the difficulty of identifying patients at high risk for pT1 non-muscle-invasive bladder cancer (NMIBC) and the difficulties in T1 substaging, tumor budding was evaluated as a potential alternative and prognostic parameter in these patients. Tumor budding as well as growth pattern, invasion ...