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The role of 25-hydroxyvitamin-D3 and vitamin D receptor gene in human periodontal ligament fibroblasts as response to orthodontic compressive strain: an in vitro study

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Küchler, Erika Calvano ; Schröder, Agnes ; Teodoro, Vinicius Broska ; Nazet, Ute ; Scariot, Rafaela ; Spanier, Gerrit ; Proff, Peter ; Kirschneck, Christian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2022 13:44


Background This study aimed to investigate, if different physiological concentrations of vitamin D (25(OH)D-3) and single nucleotide polymorphisms in vitamin D receptor (VDR) gene have an impact on gene expression in human periodontal ligament (hPDL) fibroblasts induced by simulated orthodontic compressive strain. Methods A pool of hPDL fibroblasts was treated in absence or presence of 25(OH)D-3 ...


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