Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-514064
DOI to cite this document:: 10.5283/epub.51406

Talbi, Khaoula ; Ousingsawat, Jiraporn ; Centeio, Raquel ; Schreiber, Rainer

; Kunzelmann, Karl

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Date of publication of this fulltext: 12 Jan 2022 14:07

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Abstract

Regulation of the Ca2+-activated Cl- channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent phosphatase calcineurin in TMEM16A-overexpressing HEK293 cells and TMEM16A expressed endogenously in airway and colonic epithelial cells. The activator of ...