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Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas

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Rothhammer-Hampl, Tanja ; Liesenberg, Franziska ; Hansen, Natalie ; Hoja, Sabine ; Delic, Sabit ; Reifenberger, Guido ; Riemenschneider, Markus J.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jan 2022 14:17


We previously reported that DIRAS-3 is frequently inactivated in oligodendrogliomas due to promoter hypermethylation and loss of the chromosomal arm 1p. DIRAS-3 inactivation was associated with better overall survival. Consequently, we now investigated regulation and function of its family members DIRAS-1 and DIRAS-2. We found that DIRAS-1 was strongly downregulated in 65% and DIRAS-2 in 100% of ...


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