Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-514699
DOI to cite this document:: 10.5283/epub.51469

Fritsch, Jürgen

; Frankenheim, Julia ; Marischen, Lothar ; Vadasz, Timea

; Troeger, Anja ; Rose-John, Stefan

; Schmidt-Arras, Dirk

; Schneider-Brachert, Wulf

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Date of publication of this fulltext: 20 Jan 2022 17:16

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Abstract

Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necrosome formation, which occurs in the cytoplasm. In many cell types, full apoptotic or necroptotic ...