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Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells

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Fritsch, Jürgen ; Frankenheim, Julia ; Marischen, Lothar ; Vadasz, Timea ; Troeger, Anja ; Rose-John, Stefan ; Schmidt-Arras, Dirk ; Schneider-Brachert, Wulf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jan 2022 17:16


Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necrosome formation, which occurs in the cytoplasm. In many cell types, full apoptotic or necroptotic ...


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