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Differential Expression of PD-L1 during Cell Cycle Progression of Head and Neck Squamous Cell Carcinoma

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Schulz, Daniela ; Wetzel, Martin ; Eichberger, Jonas ; Piendl, Gerhard ; Brockhoff, Gero ; Wege, Anja K. ; Reichert, Torsten ; Ettl, Tobias ; Bauer, Richard J.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jan 2022 12:43


The expression of PD-L1 by tumor cells is mainly associated with its immunosuppressive effect. In fact, PD-1/PD-L1 immune checkpoint inhibitors demonstrated remarkable effects in advanced cancer patients including HNSCC. In this context, irradiation is currently being investigated as a synergistic treatment modality to immunotherapy. However, the majority of HNSCC patients still show little ...


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