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Design and Immunological Validation of Macaca fascicularis Papillomavirus Type 3 Based Vaccine Candidates in Outbred Mice: Basis for Future Testing of a Therapeutic Papillomavirus Vaccine in NHPs

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Neckermann, Patrick ; Boilesen, Ditte Rahbaek ; Willert, Torsten ; Pertl, Cordula ; Schrödel, Silke ; Thirion, Christian ; Asbach, Benedikt ; Holst, Peter Johannes ; Wagner, Ralf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Jan 2022 13:54


Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high. Thus, an efficient therapy, such as a therapeutic vaccine, is urgently required. Herein, we describe the development and validation of Macaca fascicularis papillomavirus type 3 (MfPV3) ...


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