GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics

URN to cite this document:: urn:nbn:de:bvb:355-epub-515309
DOI to cite this document:: 10.5283/epub.51530

Ghimire, Sakhila ; Weber, Daniela ; Hippe, Katrin ; Meedt, Elisabeth ; Hoepting, Matthias ; Kattner, Anna-Sophia

; Hiergeist, Andreas

; Gessner, André

; Matos, Carina ; Ghimire, Saroj ; Wolff, Daniel

; Edinger, Matthias ; Hoffmann, Petra ; Poeck, Hendrik ; Herr, Wolfgang ; Holler, Ernst

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Date of publication of this fulltext: 27 Jan 2022 14:18

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Abstract

Microbiota can exert immunomodulatory effects by short-chain fatty acids (SCFA) in experimental models of graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-SCT). Therefore we aimed to analyze the expression of SCFAs sensing G-protein coupled receptor GPR109A and GPR43 by quantitative PCR in 338 gastrointestinal (GI) biopsies obtained from 199 adult ...