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Stanniocalcin 1 is overexpressed in multipotent mesenchymal stromal cells from acute myeloid leukemia patients

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Schelker, Roland Christian ; Kratzer, Andrea Christina ; Müller, Gunnar ; Brochhausen, Christoph ; Hart, Christina ; Stempfl, Thomas ; Heudobler, Daniel ; Moehle, Christoph ; Herr, Wolfgang ; Iberl, Sabine ; Grassinger, Jochen
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 09 Feb 2022 15:48


Objectives: Multipotent mesenchymal stromal cells (MSC) play a pivotal role in the bone marrow (BM) niche. Stanniocalcin 1 (STC1) secreted by MSC has been demonstrated to promote the survival of neoplastic cells and was suggested a marker for minimal residual disease of acute myeloid leukemia (AML). Therefore, we evaluated the expression of STC1 in MSC from AML patients (MSCAML) compared to MSC ...


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