Stanniocalcin 1 is overexpressed in multipotent mesenchymal stromal cells from acute myeloid leukemia patients

URN to cite this document:: urn:nbn:de:bvb:355-epub-516354
DOI to cite this document:: 10.5283/epub.51635

Schelker, Roland Christian ; Kratzer, Andrea Christina ; Müller, Gunnar ; Brochhausen, Christoph

; Hart, Christina ; Stempfl, Thomas ; Heudobler, Daniel ; Moehle, Christoph ; Herr, Wolfgang ; Iberl, Sabine ; Grassinger, Jochen

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Date of publication of this fulltext: 09 Feb 2022 15:48

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Abstract

Objectives: Multipotent mesenchymal stromal cells (MSC) play a pivotal role in the bone marrow (BM) niche. Stanniocalcin 1 (STC1) secreted by MSC has been demonstrated to promote the survival of neoplastic cells and was suggested a marker for minimal residual disease of acute myeloid leukemia (AML). Therefore, we evaluated the expression of STC1 in MSC from AML patients (MSCAML) compared to MSC ...