Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1-adrenergic stress induced Ca 2+ -leak from the sarcoplasmic reticulum

URN to cite this document:: urn:nbn:de:bvb:355-epub-516563
DOI to cite this document:: 10.5283/epub.51656

Baier, Maria J.

; Noack, Jannis ; Seitz, Mark Tilmann ; Maier, Lars S.

; Neef, Stefan

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Date of publication of this fulltext: 15 Feb 2022 18:56

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Abstract

Adrenergic stimulation, while being the central mechanism of cardiac positive inotropy, is a universally acknowledged inductor of undesirable sarcoplasmic reticulum (SR) Ca2+ leak. However, the exact mechanisms for this remained unspecified so far. This study shows that Ca2+/calmodulin-dependent protein kinase II (CaMKII)-specific phosphorylation of ryanodine receptor type 2 at Ser-2814 is the ...