Investigation of the HelioVital filter foil revealed protective effects against UVA1 irradiation-induced DNA damage and against UVA1-induced expression of matrixmetalloproteinases (MMP) MMP1, MMP2, MMP3 and MMP15

URN to cite this document:

urn:nbn:de:bvb:355-epub-517198 Copy

DOI to cite this document:

10.5283/epub.51719 Copy

Ivanova, I. ; Kurz, B. ; Lang, K. ; Maisch, T. ; Berneburg, M. ; Kamenisch, Y.

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License: Creative Commons Attribution 4.0 PDF - Published Version (1MB)

Date of publication of this fulltext: 22 Feb 2022 10:36

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Details

Item type:	Article
Journal or Publication Title:	Photochemical & Photobiological Sciences
Publisher:	Springer
Date:	16 February 2022
Institutions:	Medicine > Lehrstuhl für Dermatologie und Venerologie
Projects:	HelioVital GmbH
Identification Number:	Value Type 10.1007/s43630-022-00177-4 DOI
Keywords:	Ultraviolet (UV) radiation, UVA1, HelioVital filter foil, Reactive oxygen species, MMP
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	51719

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Abstract

The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320–400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' ...

Abstract

The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320–400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' -deoxyguanosine (8-OHdG). Therefore, new UV protective strategies, have to be tested for their efficiency to shield against UV induced damage. We investigated the protective effects of HelioVital sun protection filter foil against UVA1 irradiation in skin cells. It could be shown, that HelioVital sun protection filter foil has protective effects against UVA1 irradiation induced changes in matrix metalloproteinase (MMP) expression. Furthermore a UVA1-dependant regulation of MMP15 in human fibroblasts could be shown for the first time in this context. In addition, this study demonstrated the protective effect of the HelioVital filter film against UVA1-induced ROS production and DNA damage. These results could pave the way for clinical studies with HelioVital filter foil shielding against the damaging effects of phototherapy and other forms of irradiation therapy, thereby increasing the safety and treatment opportunities of these forms of therapy.

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Metadata last modified: 26 Jan 2023 15:29

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