| License: Creative Commons Attribution 4.0 PDF - Published Version (7MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-517657
- DOI to cite this document:
- 10.5283/epub.51765
Abstract
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected in clinical approvals of specific CDK4/6 ...
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