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The Renaissance of Cyclin Dependent Kinase Inhibitors

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Ettl, Tobias ; Schulz, Daniela ; Bauer, Richard Josef
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Feb 2022 08:24


Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected in clinical approvals of specific CDK4/6 ...


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