Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond

URN to cite this document:: urn:nbn:de:bvb:355-epub-518244
DOI to cite this document:: 10.5283/epub.51824

Grewal, Thomas

; Buechler, Christa

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Date of publication of this fulltext: 28 Mar 2022 14:51

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Abstract

Chronic liver diseases are commonly associated with dysregulated cholesterol metabolism. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease of the proprotein convertase family that is mainly synthetized and secreted by the liver, and represents one of the key regulators of circulating low-density lipoprotein (LDL) cholesterol levels. Its ability to bind and induce ...