Photoredox-Catalyzed Site-Selective Generation of Carbanions from C(sp3)–H Bonds in Amines

URN to cite this document:: urn:nbn:de:bvb:355-epub-519437
DOI to cite this document:: 10.5283/epub.51943

Murugesan, Kathiravan ; Donabauer, Karsten ; Narobe, Rok ; Derdau, Volker

; Bauer, Armin

; König, Burkhard

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Date of publication of this fulltext: 18 Mar 2022 11:05

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Abstract

The selective activation of sp3 carbon–hydrogen bonds in the presence of multiple C–H bonds is challenging and remains of supreme importance in chemical research. Late-stage modification of complex molecules via sp3 C–H activation is of high prevalence in organic synthesis. Herein, we describe the activation of a C(sp3)–H bond in the α-position to an amine via a carbanion intermediate. In the ...