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Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects

URN to cite this document:
urn:nbn:de:bvb:355-epub-519519
DOI to cite this document:
10.5283/epub.51951
Albert, Veruschka ; Piendl, Gerhard ; Yousseff, Dali ; Lammert, Hedwig ; Hummel, Michael ; Ortmann, Olaf ; Jagla, Wolfgang ; Gaumann, Andreas ; Wege, Anja K. ; Brockhoff, Gero
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Date of publication of this fulltext: 22 Mar 2022 05:45


Abstract

Purpose Protein kinase C (PKC) plays a pivotal role in malignant cell proliferation, apoptosis, invasiveness and migration. However, its exploitation as therapeutic target in breast cancer has been merely explored. Here were evaluated the AEB071 (Sotrastaurin™) treatment efficiency of breast cancer cell lines derived from estrogen receptor positive (T-47D), estrogen/HER2 receptor positive ...

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