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Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects

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Albert, Veruschka ; Piendl, Gerhard ; Yousseff, Dali ; Lammert, Hedwig ; Hummel, Michael ; Ortmann, Olaf ; Jagla, Wolfgang ; Gaumann, Andreas ; Wege, Anja K. ; Brockhoff, Gero
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Mar 2022 05:45


Purpose Protein kinase C (PKC) plays a pivotal role in malignant cell proliferation, apoptosis, invasiveness and migration. However, its exploitation as therapeutic target in breast cancer has been merely explored. Here were evaluated the AEB071 (Sotrastaurin™) treatment efficiency of breast cancer cell lines derived from estrogen receptor positive (T-47D), estrogen/HER2 receptor positive ...


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