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Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects

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Albert, Veruschka ; Piendl, Gerhard ; Yousseff, Dali ; Lammert, Hedwig ; Hummel, Michael ; Ortmann, Olaf ; Jagla, Wolfgang ; Gaumann, Andreas ; Wege, Anja K. ; Brockhoff, Gero
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Mar 2022 05:45

This publication is part of the DEAL contract with Springer.


Purpose Protein kinase C (PKC) plays a pivotal role in malignant cell proliferation, apoptosis, invasiveness and migration. However, its exploitation as therapeutic target in breast cancer has been merely explored. Here were evaluated the AEB071 (Sotrastaurin (TM)) treatment efficiency of breast cancer cell lines derived from estrogen receptor positive (T-47D), estrogen/HER2 receptor positive ...


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