Go to content
UR Home

Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders

URN to cite this document:
DOI to cite this document:
Peters, Sebastian Thomas ; Wirkert, Eva ; Kuespert, Sabrina ; Heydn, Rosmarie ; Johannesen, Siw Wollebæk ; Friedrich, Anita ; Mailänder, Susanne ; Korte, Sven ; Mecklenburg, Lars ; Aigner, Ludwig ; Bruun, Tim-Henrik ; Bogdahn, Ulrich
License: Creative Commons Attribution 4.0
PDF - Published Version
Date of publication of this fulltext: 28 Mar 2022 12:57


The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamental hallmarks in the disease course of neurodegenerative disorders. We and others have demonstrated the endogenous TGF beta system to represent a ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons