Stepwise assembly of the eukaryotic translation initiation factor 2 complex

URN to cite this document:: urn:nbn:de:bvb:355-epub-519837
DOI to cite this document:: 10.5283/epub.51983

Vanselow, Sven ; Neumann-Arnold, Lea ; Wojciech-Moock, Franziska ; Seufert, Wolfgang

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Date of publication of this fulltext: 28 Mar 2022 14:29

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Abstract

The eukaryotic translation initiation factor 2 (eIF2) has key functions in the initiation step of protein synthesis. eIF2 guides the initiator tRNA to the ribosome, participates in scanning of the mRNA molecule, supports selection of the start codon, and modulates the translation of mRNAs in response to stress. eIF2 comprises a heterotrimeric complex whose assembly depends on the ATP-grasp ...