Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear

URN to cite this document:: urn:nbn:de:bvb:355-epub-519998
DOI to cite this document:: 10.5283/epub.51999

Royer, Melanie ; Pai, Balagopal

; Menon, Rohit ; Bludau, Anna

; Gryksa, Katharina ; Perry, Rotem Ben-Tov ; Ulitsky, Igor

; Meister, Gunter ; Neumann, Inga D.

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(4MB)

Date of publication of this fulltext: 29 Mar 2022 04:48

Alternative links to fulltext:DOI Publisher

This publication is part of the DEAL contract with Springer.

Details

Preview

Indexed in

Export bibliographical data

Abstract

Social anxiety disorder is characterized by a persistent fear and avoidance of social situations, but available treatment options are rather unspecific. Using an established mouse social fear conditioning (SFC) paradigm, we profiled gene expression and chromatin alterations after the acquisition and extinction of social fear within the septum, a brain region important for social fear and social ...