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Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear

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Royer, Melanie ; Pai, Balagopal ; Menon, Rohit ; Bludau, Anna ; Gryksa, Katharina ; Perry, Rotem Ben-Tov ; Ulitsky, Igor ; Meister, Gunter ; Neumann, Inga D.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Mar 2022 04:48

This publication is part of the DEAL contract with Springer.


Social anxiety disorder is characterized by a persistent fear and avoidance of social situations, but available treatment options are rather unspecific. Using an established mouse social fear conditioning (SFC) paradigm, we profiled gene expression and chromatin alterations after the acquisition and extinction of social fear within the septum, a brain region important for social fear and social ...


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