IRAG2 Interacts with IP3-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca2+ in Murine Pancreatic Acinar Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-520397
DOI to cite this document:: 10.5283/epub.52039

Prüschenk, Sally ; Majer, Michael

; Schreiber, Rainer

; Schlossmann, Jens

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Date of publication of this fulltext: 05 Apr 2022 04:53

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Abstract

The inositol 1,4,5-triphosphate receptor-associated 2 (IRAG2) is also known as Jaw1 or lymphoid-restricted membrane protein (LRMP) and shares homology with the inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate 1 (IRAG1). IRAG1 interacts with inositol trisphosphate receptors (IP3 receptors /IP3R) via its coiled-coil domain and modulates Ca2+ release from intracellular stores. ...