Low intestinal IL22 associates with increased transplant-related mortality after allogeneic stem cell transplantation

URN to cite this document:: urn:nbn:de:bvb:355-epub-520438
DOI to cite this document:: 10.5283/epub.52043

Ghimire, Sakhila ; Ederer, Katharina U. ; Meedt, Elisabeth ; Weber, Daniela ; Matos, Carina

; Hiergeist, Andreas

; Zeman, Florian ; Wolff, Daniel

; Edinger, Matthias ; Poeck, Hendrik ; Herr, Wolfgang ; Gessner, Andre ; Holler, Ernst ; Bülow, Sigrid

License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 30 Mar 2022 15:38

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated ...