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Low intestinal IL22 associates with increased transplant-related mortality after allogeneic stem cell transplantation

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Ghimire, Sakhila ; Ederer, Katharina U. ; Meedt, Elisabeth ; Weber, Daniela ; Matos, Carina ; Hiergeist, Andreas ; Zeman, Florian ; Wolff, Daniel ; Edinger, Matthias ; Poeck, Hendrik ; Herr, Wolfgang ; Gessner, Andre ; Holler, Ernst ; Bülow, Sigrid
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Date of publication of this fulltext: 30 Mar 2022 15:38


The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated ...


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