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Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma

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Erber, Ramona ; Spoerl, Steffen ; Mamilos, Andreas ; Krupar, Rosemarie ; Hartmann, Arndt ; Ruebner, Matthias ; Taxis, Juergen ; Wittenberg, Mareike ; Reichert, Torsten E. ; Spanier, Gerrit ; Spoerl, Silvia
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Apr 2022 04:55


Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of ...


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