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Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice

DOI to cite this document:
10.5283/epub.52094
Fuchs, Michaela A. A. ; Schrankl, Julia ; Leupold, Christina ; Wagner, Charlotte ; Kurtz, Armin ; Broeker, Katharina A.-E.
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Date of publication of this fulltext: 07 Apr 2022 04:31


Abstract

Cyclooxygenase (Cox) inhibitors are known to have severe side effects during renal development. These consist of reduced re-nal function, underdeveloped subcapsular glomeruli, interstitialfibrosis, and thinner cortical tissue. Global genetic deletion ofCox-2 mimics the phenotype observed after application of Cox inhibitors. This study aimed to investigate which cell typesexpress ...

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