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Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice

DOI to cite this document:
Fuchs, Michaela A. A. ; Schrankl, Julia ; Leupold, Christina ; Wagner, Charlotte ; Kurtz, Armin ; Broeker, Katharina A.-E.
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Date of publication of this fulltext: 07 Apr 2022 04:31


Cyclooxygenase (Cox) inhibitors are known to have severe side effects during renal development. These consist of reduced renal function, underdeveloped subcapsular glomeruli, interstitial fibrosis, and thinner cortical tissue. Global genetic deletion of Cox-2 mimics the phenotype observed after application of Cox inhibitors. This study aimed to investigate which cell types express Cox-2 and ...


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