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Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice

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Haberl, Elisabeth M. ; Pohl, Rebekka ; Rein-Fischboeck, Lisa ; Höring, Marcus ; Krautbauer, Sabrina ; Liebisch, Gerhard ; Buechler, Christa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Apr 2022 15:12


Background Dysregulated lipid metabolism is critically involved in the development of hepatocellular carcinoma (HCC). The respective metabolic pathways affected in HCC can be identified using suitable experimental models. Mice injected with diethylnitrosamine (DEN) and fed a normal chow develop HCC. For the analysis of the pathophysiology of HCC in this model a comprehensive lipidomic analysis ...


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