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Ribavirin Improves NK Cell IFNγ Response During Sofosbuvir-based DAA Therapy in HCV-infected Liver Transplant Recipients

DOI to cite this document:
10.5283/epub.52106
Adenugba, Akinbami ; Hornung, Matthias ; Weigand, Kilian ; Peschel, Georg ; Junger, Henrik ; Kupke, Paul ; Lang, Hauke ; Marquardt, Jens U. ; Zimmermann, Tim ; Geissler, Edward K. ; Schlitt, Hans J. ; Werner, Jens M.
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Date of publication of this fulltext: 07 Apr 2022 04:38



Abstract

Background. Chronic hepatitis C virus (HCV) infection is characterized by activation of natural killer (NK) cells. Here, we asked whether HCV elimination by sofosbuvir-based direct-acting antivirals (DAAs) and the addition of ribavirin (RBV) improve NK cell function in liver transplant (LTx) recipients. Methods. We analyzed NK cell degranulation and interferon (IFN)gamma-response along with STAT1 ...

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