Ribavirin Improves NK Cell IFNγ Response During Sofosbuvir-based DAA Therapy in HCV-infected Liver Transplant Recipients

DOI to cite this document:: 10.5283/epub.52106

Adenugba, Akinbami ; Hornung, Matthias

; Weigand, Kilian

; Peschel, Georg ; Junger, Henrik ; Kupke, Paul ; Lang, Hauke ; Marquardt, Jens U. ; Zimmermann, Tim ; Geissler, Edward K.

; Schlitt, Hans J.

; Werner, Jens M.

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Date of publication of this fulltext: 07 Apr 2022 04:38

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Abstract

Background. Chronic hepatitis C virus (HCV) infection is characterized by activation of natural killer (NK) cells. Here, we asked whether HCV elimination by sofosbuvir-based direct-acting antivirals (DAAs) and the addition of ribavirin (RBV) improve NK cell function in liver transplant (LTx) recipients. Methods. We analyzed NK cell degranulation and interferon (IFN)gamma-response along with ...