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Monitoring B cell alloresponses in rats

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Steines, Louisa ; Scharf, Mona ; Hoffmann, Petra ; Schuster, Antonia Margarete ; Banas, Bernhard ; Bergler, Tobias
Date of publication of this fulltext: 07 Apr 2022 04:39


Antibody-mediated rejection is a major cause of graft failure in organ transplantation. For this reason, B cell responses are of particular interest to transplantation research. Rats are important model organisms for transplant studies, but B cell alloimmune assays and B cell subset markers are poorly established in rats. We alloimmunized rats by donor blood injection using the high responder rat ...


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