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EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients

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Mederer, Tobias ; Elsner, Felix ; Robold, Tobias ; Großer, Christian ; Neu, Reiner ; Ried, Michael ; Bleicher, Sabine ; Schamberger, Thomas ; Blochberger, Isabell ; Hofmann, Hans-Stefan ; Klein, Christoph A.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Apr 2022 04:48


Introduction: Detection of disseminated cancer cells (DCC) in bone marrow (BM) of patients with early-stage NSCLC has been associated with poor outcome. However, the phenotype, and hence relevant therapy targets, of DCCs in BM are unknown. We therefore compared a classical pan-Cytokeratin (CK) antibody for DCC detection with an anti-EpCAM antibody that may also detect more stem-like cells and ...


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