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Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin‐expressing cells of mouse kidneys

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Broeker, Katharina A. E. ; Fuchs, Michaela A. A. ; Schrankl, Julia ; Lehrmann, Claudia ; Schley, Gunnar ; Todorov, Vladimir T. ; Hugo, Christian ; Wagner, Charlotte ; Kurtz, Armin

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Date of publication of this fulltext: 07 Apr 2022 12:17

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Activation of the hypoxia-signalling pathway induced by deletion of the ubiquitin-ligase von Hippel–Lindau protein causes an endocrine shift of renin-producing cells to erythropoietin (EPO)-expressing cells. However, the underlying mechanisms have not yet been investigated. Since oxygen-regulated stability of hypoxia-inducible transcription factors relevant for EPO expression is dependent on the ...


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