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Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon

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Delgado Caceres, Manuel ; Angerpointner, Katharina ; Galler, Michael ; Lin, Dasheng ; Michel, Philipp A. ; Brochhausen, Christoph ; Lu, Xin ; Varadarajan, Adithi R. ; Warfsmann, Jens ; Stange, Richard ; Alt, Volker ; Pfeifer, Christian G. ; Docheva, Denitsa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Apr 2022 14:59


Heterotopic ossification (HO) represents a common problem after tendon injury with no effective treatment yet being developed. Tenomodulin (Tnmd), the best-known mature marker for tendon lineage cells, has important effects in tendon tissue aging and function. We have reported that loss of Tnmd leads to inferior early tendon repair characterized by fibrovascular scaring and therefore hypothesized ...


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