Detection of Incomplete Irreversible Electroporation (IRE) and Microwave Ablation (MWA) of Hepatocellular Carcinoma (HCC) Using Iodine Quantification in Dual Energy Computed Tomography (DECT)

URN to cite this document:

urn:nbn:de:bvb:355-epub-521819 Copy

DOI to cite this document:

10.5283/epub.52181 Copy

Bäumler, Wolf ; Beyer, Lukas Philipp ; Lürken, Lukas ; Wiggermann, Philipp ; Stroszczynski, Christian ; Dollinger, Marco ; Schicho, Andreas

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Date of publication of this fulltext: 22 Apr 2022 15:53

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	1545.18
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Diagnostics
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	12
Number of Issue or Book Chapter:	4
Page Range:	p. 986
Date:	14 April 2022
Institutions:	Medicine > Lehrstuhl für Röntgendiagnostik
Identification Number:	Value Type 10.3390/diagnostics12040986 DOI
Keywords:	TUMOR ABLATION; THERMAL ABLATION; EFFICACY; SAFETY; STANDARDIZATION; TERMINOLOGY; RECURRENCE; MODEL; dual-energy computed tomography; irreversible electroporation; microwave ablation; hepatocellular carcinoma; residual tumor; iodine uptake
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	52181

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Abstract

Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this study was to identify cases with insufficient ablation and prevent HCC recurrencies by measuring iodine uptake using dual-energy computed tomography (DECT). In 54 HCC-patients, the volumetric iodine ...

Abstract

Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this study was to identify cases with insufficient ablation and prevent HCC recurrencies by measuring iodine uptake using dual-energy computed tomography (DECT). In 54 HCC-patients, the volumetric iodine concentration (VIC) of the central and peripheral ablation area was evaluated by DECT within 24 h after IRE or MWA. Follow-up was performed with CT and/or MRI at 6 weeks, 3, 6, 9, and 12 months, respectively. In both groups, LTP was solely detected in the peripheral area (IRE: n = 4; MWA: n = 4) and LTP patients showed significantly higher VIC values in the peripheral zone than patients without LTP (IRE: * p = 0.0005; MWA: * p = 0.000). In IRE-LTP patients, no significant difference between the VIC values of non-ablated liver tissue and the peripheral zone was detected (p = 0.155). The peripheral zones of IRE patients without LTP (* p = 0.000) and MWA patients, irrespective of the presence of LTP (LTP: * p = 0.005; without LTP: * p = 0.000), showed significantly lower VIC values than non-ablated liver parenchyma. Higher BCLC tumor stages were indicative for LTP (* p = 0.008). The study suggests that elevated iodine uptake in the peripheral ablation zone could help identify LTP after IRE and MWA of HCC.

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Metadata last modified: 28 Apr 2022 16:42

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