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Impact of phosphorylation of heat shock protein 27 on the expression profile of periodontal ligament fibroblasts during mechanical strain

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Schröder, Agnes ; Wagner, Kathrin ; Cieplik, Fabian ; Spanier, Gerrit ; Proff, Peter ; Kirschneck, Christian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 May 2022 08:11

This publication is part of the DEAL contract with Springer.


Purpose Orthodontic tooth movement is a complex process involving the remodeling of extracellular matrix and bone as well as inflammatory processes. During orthodontic treatment, sterile inflammation and mechanical loading favor the production of receptor activator of NF-κB ligand (RANKL). Simultaneously, expression of osteoprotegerin (OPG) is inhibited. This stimulates bone resorption on the ...


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