Impact of phosphorylation of heat shock protein 27 on the expression profile of periodontal ligament fibroblasts during mechanical strain

URN to cite this document:: urn:nbn:de:bvb:355-epub-522375
DOI to cite this document:: 10.5283/epub.52237

Schröder, Agnes

; Wagner, Kathrin ; Cieplik, Fabian

; Spanier, Gerrit

; Proff, Peter ; Kirschneck, Christian

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Date of publication of this fulltext: 13 May 2022 08:11

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Abstract

Purpose Orthodontic tooth movement is a complex process involving the remodeling of extracellular matrix and bone as well as inflammatory processes. During orthodontic treatment, sterile inflammation and mechanical loading favor the production of receptor activator of NF-κB ligand (RANKL). Simultaneously, expression of osteoprotegerin (OPG) is inhibited. This stimulates bone resorption on the ...