Hepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-522415
DOI to cite this document:: 10.5283/epub.52241

Pohl, Rebekka ; Eichelberger, Laura ; Feder, Susanne ; Haberl, Elisabeth M.

; Rein-Fischboeck, Lisa ; McMullen, Nichole

; Sinal, Christopher J. ; Bruckmann, Astrid ; Weiss, Thomas S.

; Beck, Michael ; Höring, Marcus

; Krautbauer, Sabrina ; Liebisch, Gerhard

; Wiest, Reiner ; Wanninger, Josef ; Buechler, Christa

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Date of publication of this fulltext: 24 May 2022 05:41

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Abstract

Non-alcoholic steatohepatitis (NASH) is a rapidly growing liver disease. The chemoattractant chemerin is abundant in hepatocytes, and hepatocyte expressed prochemerin protected from NASH. Prochemerin is inactive and different active isoforms have been described. Here, the effect of hepatocyte expressed muChem-156, a highly active murine chemerin isoform, was studied in the methionine-choline ...