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Hepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis

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Pohl, Rebekka ; Eichelberger, Laura ; Feder, Susanne ; Haberl, Elisabeth M. ; Rein-Fischboeck, Lisa ; McMullen, Nichole ; Sinal, Christopher J. ; Bruckmann, Astrid ; Weiss, Thomas S. ; Beck, Michael ; Höring, Marcus ; Krautbauer, Sabrina ; Liebisch, Gerhard ; Wiest, Reiner ; Wanninger, Josef ; Buechler, Christa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 24 May 2022 05:41

This publication is part of the DEAL contract with Springer.


Non-alcoholic steatohepatitis (NASH) is a rapidly growing liver disease. The chemoattractant chemerin is abundant in hepatocytes, and hepatocyte expressed prochemerin protected from NASH. Prochemerin is inactive and different active isoforms have been described. Here, the effect of hepatocyte expressed muChem-156, a highly active murine chemerin isoform, was studied in the methionine-choline ...


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