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Identification of a core gene-regulatory trajectory to terminal T cell dysfunction in human tumors and discovery of potential target genes involved in this process

URN to cite this document:
urn:nbn:de:bvb:355-epub-522947
DOI to cite this document:
10.5283/epub.52294
Riegel, Dania
Date of publication of this fulltext: 15 May 2023 06:38


Abstract (English)

Diseases such as cancer are often associated with suppression of the immune sys- tem. Thereby, cytotoxic CD8+ T cells, originally meant to kill the cancerous cells, tend to become dysfunctional, as they are struggling with long term exposure to antigens and the immunosuppressive tumor microenvironment. As a consequence, tumor-specific CD8+ T cells often fail to fully eliminate cancer cells. Much ...

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Translation of the abstract (German)

Krankheiten wie Krebs stehen oft im Zusammenhang mit einer Unterdrückung des Immunsystems. Es wurde beobachtet, dass zytotoxische CD8+ T-Zellen, die eigentlich entartete Krebszellen zerstören sollen, dysfunktional werden. Als Grund dafür werden die langanhaltende Tumor-Antigenpräsentation und das immunsupprimierende Tumormikromilieu genannt. Infolgedessen gelingt es tumorspezifischen CD8+ ...

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