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Identification of a core gene-regulatory trajectory to terminal T cell dysfunction in human tumors and discovery of potential target genes involved in this process

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Riegel, Dania
Date of publication of this fulltext: 15 May 2023 06:38

Abstract (English)

Diseases such as cancer are often associated with suppression of the immune sys- tem. Thereby, cytotoxic CD8+ T cells, originally meant to kill the cancerous cells, tend to become dysfunctional, as they are struggling with long term exposure to antigens and the immunosuppressive tumor microenvironment. As a consequence, tumor-specific CD8+ T cells often fail to fully eliminate cancer cells. Much ...


Translation of the abstract (German)

Krankheiten wie Krebs stehen oft im Zusammenhang mit einer Unterdrückung des Immunsystems. Es wurde beobachtet, dass zytotoxische CD8+ T-Zellen, die eigentlich entartete Krebszellen zerstören sollen, dysfunktional werden. Als Grund dafür werden die langanhaltende Tumor-Antigenpräsentation und das immunsupprimierende Tumormikromilieu genannt. Infolgedessen gelingt es tumorspezifischen CD8+ ...


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