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The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

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Cigliano, Antonio ; Zhang, Shanshan ; Ribback, Silvia ; Steinmann, Sara ; Sini, Marcella ; Ament, Cindy E. ; Utpatel, Kirsten ; Song, Xinhua ; Wang, Jingxiao ; Pilo, Maria G. ; Berger, Fabian ; Wang, Haichuan ; Tao, Junyan ; Li, Xiaolei ; Pes, Giovanni M. ; Mancarella, Serena ; Giannelli, Gianluigi ; Dombrowski, Frank ; Evert, Matthias ; Calvisi, Diego F. ; Chen, Xin ; Evert, Katja
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Jun 2022 05:45


Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms whereby the Hippo cascade contributes to cholangiocarcinogenesis remain poorly defined. Methods We ...


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