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Investigating the ligand agonism and antagonism at the D2long receptor by dynamic mass redistribution

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Forster, Lisa ; Pockes, Steffen
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Jun 2022 05:22


The signalling of the D-2 receptor (D2R), a G protein-coupled receptor (GPCR), is a complex process consisting of various components. For the screening of D2R ligands, methods quantifying distinct second messengers such as cAMP or the interaction of the receptor with p-arrestin, are commonly employed. In contrast, a label-free biosensor technology like dynamic mass redistribution (DMR), where it ...


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