Investigating the ligand agonism and antagonism at the D2long receptor by dynamic mass redistribution

URN to cite this document:: urn:nbn:de:bvb:355-epub-524319
DOI to cite this document:: 10.5283/epub.52431

Forster, Lisa ; Pockes, Steffen

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Date of publication of this fulltext: 21 Jun 2022 05:22

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Abstract

The signalling of the D-2 receptor (D2R), a G protein-coupled receptor (GPCR), is a complex process consisting of various components. For the screening of D2R ligands, methods quantifying distinct second messengers such as cAMP or the interaction of the receptor with p-arrestin, are commonly employed. In contrast, a label-free biosensor technology like dynamic mass redistribution (DMR), where it ...