| License: Creative Commons Attribution 4.0 PDF - Published Version (8MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-525682
- DOI to cite this document:
- 10.5283/epub.52568
Abstract
Human Argonaute 2 (hAgo2) constitutes the functional core of the RNA interference pathway. Guide RNAs direct hAgo2 to target mRNAs, which ultimately leads to hAgo2-mediated mRNA degradation or translational inhibition. Here, we combine site-specifically labeled hAgo2 with time-resolved single-molecule FRET measurements to monitor conformational states and dynamics of hAgo2 and hAgo2-RNA complexes ...

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