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Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2

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Willkomm, Sarah ; Jakob, Leonhard ; Kramm, Kevin ; Graus, Veronika ; Neumeier, Julia ; Meister, Gunter ; Grohmann, Dina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 06 Jul 2022 04:40


Human Argonaute 2 (hAgo2) constitutes the functional core of the RNA interference pathway. Guide RNAs direct hAgo2 to target mRNAs, which ultimately leads to hAgo2-mediated mRNA degradation or translational inhibition. Here, we combine site-specifically labeled hAgo2 with time-resolved single-molecule FRET measurements to monitor conformational states and dynamics of hAgo2 and hAgo2-RNA complexes ...


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