Dickkopf 3—A New Indicator for the Deterioration of Allograft Function After Kidney Transplantation

URN to cite this document:: urn:nbn:de:bvb:355-epub-525926
DOI to cite this document:: 10.5283/epub.52592

Schuster, Antonia Margarete

; Steines, Louisa ; Müller, Karolina

; Zeman, Florian ; Findeisen, Peter ; Banas, Bernhard

; Bergler, Tobias

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Date of publication of this fulltext: 14 Jul 2022 05:56

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Abstract

Evidence of tubular atrophy and interstitial fibrosis is prognostically unfavorable and associated with a premature graft loss after kidney transplantation. Recently, Dickkopf 3 (DKK3), a profibrotic glycoprotein released by stressed tubular epithelial cells, has been identified to cause IF/TA by regulating the Wnt/β-catenin signaling and seems to engage a T-cell response. The aim of our study ...