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Dickkopf 3—A New Indicator for the Deterioration of Allograft Function After Kidney Transplantation

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Schuster, Antonia Margarete ; Steines, Louisa ; Müller, Karolina ; Zeman, Florian ; Findeisen, Peter ; Banas, Bernhard ; Bergler, Tobias
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Jul 2022 05:56


Evidence of tubular atrophy and interstitial fibrosis is prognostically unfavorable and associated with a premature graft loss after kidney transplantation. Recently, Dickkopf 3 (DKK3), a profibrotic glycoprotein released by stressed tubular epithelial cells, has been identified to cause IF/TA by regulating the Wnt/beta-catenin signaling and seems to engage a T-cell response. The aim of our study ...


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