Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-525982
DOI to cite this document:: 10.5283/epub.52598

Estrela, Karolyne A. R. ; Senninger, Lisa ; Arndt, Josephine ; Kabas, Melanie ; Schmid, Ferdinand ; Dillmann, Larissa

; Auer, Sophia ; Stepfer, Thomas ; Flor, Peter J. ; Uschold-Schmidt, Nicole

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 14 Jul 2022 07:54

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Chronic psychosocial stress participates prominently in the etiology of various psychiatric conditions and comorbid somatic pathologies; however, suitable pharmacotherapy of these disorders is still of high medical need. During the last few decades, research on mGlu receptors advanced remarkably and much attention was given to the mGlu7 subtype. Here, genetic mGlu7 ablation, short-term ...