Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea–An Analysis From the SERVE-HF Major Substudy

URN to cite this document:

urn:nbn:de:bvb:355-epub-526145 Copy

DOI to cite this document:

10.5283/epub.52614 Copy

Fisser, Christoph ; Gall, Lara ; Bureck, Jannis ; Vaas, Victoria ; Priefert, Jörg ; Fredersdorf, Sabine ; Zeman, Florian ; Linz, Dominik ; Woehrle, Holger ; Tamisier, Renaud ; Teschler, Helmut ; Cowie, Martin R. ; Arzt, Michael

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Date of publication of this fulltext: 26 Jul 2022 09:18

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	2633.93
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Frontiers in Cardiovascular Medicine
Publisher:	Frontiers
Place of Publication:	LAUSANNE
Volume:	9
Page Range:	p. 896917
Date:	20 June 2022
Institutions:	Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien
Projects (Historical):	German Heart Foundation/German Foundation of Heart Researche (F/15/20)
Identification Number:	Value Type 10.3389/fcvm.2022.896917 DOI
Keywords:	POSITIVE AIRWAY PRESSURE; MORTALITY; ASSOCIATION; COMPLEXES; ECTOPY; RISK; heart failure; central sleep apnoea; adaptive servo-ventilation; ventricular arrhythmias; SERVE-HF
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	52614

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Abstract

BackgroundThe SERVE-HF trial investigated the effect of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with heart failure with reduced ejection fraction (HFrEF). ObjectiveThe aim of the present ancillary analysis of the SERVE-HF major substudy (NCT01164592) was to assess the effects of ASV on the burden of nocturnal ventricular arrhythmias as one possible ...

Abstract

BackgroundThe SERVE-HF trial investigated the effect of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with heart failure with reduced ejection fraction (HFrEF). ObjectiveThe aim of the present ancillary analysis of the SERVE-HF major substudy (NCT01164592) was to assess the effects of ASV on the burden of nocturnal ventricular arrhythmias as one possible mechanism for sudden cardiac death in ASV-treated patients with HFrEF and CSA. MethodsThree hundred twelve patients were randomized in the SERVE-HF major substudy [no treatment of CSA (control) vs. ASV]. Polysomnography including nocturnal ECG fulfilling technical requirements was performed at baseline, and at 3 and 12 months. Premature ventricular complexes (events/h of total recording time) and non-sustained ventricular tachycardia were assessed. Linear mixed models and generalized linear mixed models were used to analyse differences between the control and ASV groups, and changes over time. ResultsFrom baseline to 3- and 12-month follow-up, respectively, the number of premature ventricular complexes (control: median 19.7, 19.0 and 19.0; ASV: 29.1, 29.0 and 26.0 events/h; p = 0.800) and the occurrence of >= 1 non-sustained ventricular tachycardia/night (control: 18, 25, and 18% of patients; ASV: 24, 16, and 24% of patients; p = 0.095) were similar in the control and ASV groups. ConclusionAddition of ASV to guideline-based medical management had no significant effect on nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months in alive patients with HFrEF and CSA. Findings do not further support the hypothesis that ASV may lead to sudden cardiac death by triggering ventricular tachyarrhythmia.

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Metadata last modified: 20 Jan 2025 14:45

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