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Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology

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Biasella, Fabiola ; Strunz, Tobias ; Kiel, Christina ; Weber, Bernhard H. F. ; Friedrich, Ulrike
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jul 2022 09:24


The pathogenesis of age-related macular degeneration (AMD), a frequent disorder of the central retina, is incompletely understood. Genome-wide association studies (GWAS) suggest a strong contribution of genomic variation in AMD susceptibility. Nevertheless, little is known about biological mechanisms of the disease. We reported previously that the AMD-associated polymorphism rs704C > T in the ...


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