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Postmitotic differentiation of human monocytes requires cohesin-structured chromatin

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Minderjahn, Julia ; Fischer, Alexander ; Maier, Konstantin ; Mendes, Karina ; Nuetzel, Margit ; Raithel, Johanna ; Stanewsky, Hanna ; Ackermann, Ute ; Månsson, Robert ; Gebhard, Claudia ; Rehli, Michael
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Date of publication of this fulltext: 27 Jul 2022 06:03


Cohesin is a major structural component of mammalian genomes and is required to maintain loop structures. While acute depletion in short-term culture models suggests a limited importance of cohesin for steady-state transcriptional circuits, long-term studies are hampered by essential functions of cohesin during replication. Here, we study genome architecture in a postmitotic differentiation ...


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