Postmitotic differentiation of human monocytes requires cohesin-structured chromatin

URN to cite this document:: urn:nbn:de:bvb:355-epub-526700
DOI to cite this document:: 10.5283/epub.52670

Minderjahn, Julia ; Fischer, Alexander

; Maier, Konstantin ; Mendes, Karina

; Nuetzel, Margit ; Raithel, Johanna ; Stanewsky, Hanna ; Ackermann, Ute ; Månsson, Robert ; Gebhard, Claudia

; Rehli, Michael

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Jul 2022 06:03

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Abstract

Cohesin is a major structural component of mammalian genomes and is required to maintain loop structures. While acute depletion in short-term culture models suggests a limited importance of cohesin for steady-state transcriptional circuits, long-term studies are hampered by essential functions of cohesin during replication. Here, we study genome architecture in a postmitotic differentiation ...