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Apheresis for chimeric antigen receptor T‐cell production in adult lymphoma patients

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Harrer, Dennis Christoph ; Heidenreich, Martin ; Fante, Matthias Alexander ; Müller, Viktoria ; Hähnel, Viola ; Offner, Robert ; Burkhardt, Ralph ; Herr, Wolfgang ; Edinger, Matthias ; Wolff, Daniel ; Thomas, Simone ; Brosig, Andreas
Date of publication of this fulltext: 09 Aug 2022 04:50

This publication is part of the DEAL contract with Wiley.


Background To date, in-depth analysis of leukapheresis products as starting material for CAR T-cell manufacturing, specifically Tisagenlecleucel production, are scarce. In this study, we report on lymphapheresis data for production of Tisagenlecleucel for elderly and pretreated lymphoma patients. Study Design and Methods Spectra Optia from Terumo BCT, Lakewood, CO, was employed for apheresis ...


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