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Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities

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Scheiter, Alexander ; Hierl, Frederik ; Winkel, Ingrid ; Keil, Felix ; Klier-Richter, Margit ; Coulouarn, Cédric ; Lüke, Florian ; Kandulski, Arne ; Evert, Matthias ; Dietmaier, Wolfgang ; Calvisi, Diego F. ; Utpatel, Kirsten
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Date of publication of this fulltext: 17 Aug 2022 08:22


Cholangiocarcinoma (CCA) features a dismal prognosis with limited treatment options. Genomic studies have unveiled several promising targets in this disease, including fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH) mutations. To fully harness the potential of genomically informed therapies in CCA, it is necessary to thoroughly characterize the available model ...


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