Wnt/β-Catenin-Pathway Alterations and Homologous Recombination Deficiency in Cholangiocarcinoma Cell Lines and Clinical Samples: Towards Specific Vulnerabilities

URN to cite this document:: urn:nbn:de:bvb:355-epub-527664
DOI to cite this document:: 10.5283/epub.52766

Scheiter, Alexander

; Hierl, Frederik ; Winkel, Ingrid ; Keil, Felix ; Klier-Richter, Margit ; Coulouarn, Cédric ; Lüke, Florian ; Kandulski, Arne ; Evert, Matthias ; Dietmaier, Wolfgang ; Calvisi, Diego F. ; Utpatel, Kirsten

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Date of publication of this fulltext: 17 Aug 2022 08:22

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Abstract

Cholangiocarcinoma (CCA) features a dismal prognosis with limited treatment options. Genomic studies have unveiled several promising targets in this disease, including fibroblast growth factor receptor (FGFR) fusions and isocitrate dehydrogenase (IDH) mutations. To fully harness the potential of genomically informed therapies in CCA, it is necessary to thoroughly characterize the available model ...