β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-527884
DOI to cite this document:: 10.5283/epub.52788

Honke, Nadine

; Wiest, Clemens J. ; Pongratz, Georg

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Aug 2022 14:07

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Abstract

The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. In the past, treatment of arthritic B cells with a beta 2-adrenergic receptor (beta 2-ADR) agonist has been shown to attenuate arthritis. In this study, the expression and signaling of beta 2-ADR in B cells during collagen-induced arthritis (CIA) were investigated ...