Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

URN to cite this document:: urn:nbn:de:bvb:355-epub-528072
DOI to cite this document:: 10.5283/epub.52807

Wang, Chenglong ; Stöckl, Sabine ; Li, Shushan ; Herrmann, Marietta ; Lukas, Christoph ; Reinders, Yvonne ; Sickmann, Albert ; Grässel, Susanne

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Aug 2022 14:55

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Abstract

Osteoporosis, or steroid-induced osteonecrosis of the hip, is accompanied by increased bone marrow adipogenesis. Such a disorder of adipogenic/osteogenic differentiation, affecting bone-marrow-derived mesenchymal stem cells (BMSCs), contributes to bone loss during aging. Here, we investigated the effects of extracellular vesicles (EVs) isolated from human (h)BMSCs during different stages of ...