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Stürzl, Roman ; Gerken, Michael ; Bruns, Christiane ; Klinkhammer-Schalke, Monika ; Pauer, Armin ; Piso, Pompiliu

Chirurgische Therapie des Adenokarzinoms des ösophagogastralen Übergangs Typ II : Vergleich zwischen transhiatal erweiterter Gastrektomie und thorakoabdomineller Ösophagektomie

Stürzl, Roman, Gerken, Michael, Bruns, Christiane, Klinkhammer-Schalke, Monika, Pauer, Armin and Piso, Pompiliu (2022) Chirurgische Therapie des Adenokarzinoms des ösophagogastralen Übergangs Typ II : Vergleich zwischen transhiatal erweiterter Gastrektomie und thorakoabdomineller Ösophagektomie. Die Chirurgie.

Date of publication of this fulltext: 30 Aug 2022 06:43
Article
DOI to cite this document: 10.5283/epub.52827


Abstract

Background: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has significantly increased. However, the best surgical treatment for AEG type II is still the subject of current research. The goal of this retrospective cohort study is to compare survival and recurrence rates in patients, who underwent either thoracoabdominal esophagectomy (TAE) or transhiatal extended ...

Background: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has significantly increased. However, the best surgical treatment for AEG type II is still the subject of current research. The goal of this retrospective cohort study is to compare survival and recurrence rates in patients, who underwent either thoracoabdominal esophagectomy (TAE) or transhiatal extended gastrectomy (TEG). Material and methods: The study is based on a cohort of 272 patients diagnosed with AEG type II between 2002 and 2020, recorded by a population-based clinical cancer registry. Of the included patients 63 underwent TAE and 209 TEG. In order to compare overall survival, recurrence rates, and recurrence free survival, we applied the Kaplan-Meier method, univariable and multivariable Cox regression. Results: Our analysis showed no statistically significant difference concerning overall survival (p = 0.333). However a tendency towards higher survival rates after TAE for the period from 2016-2020 (p = 0,058) is possible. In contrast a significant difference concerning higher cumulative recurrence rates after TAE was found after Kaplan-Meier analysis (p = 0.049). This trend was not observed for the time after 2016 (p = 0.993), in which over 50% of TAE were performed. No differences were found regarding recurrence-free survival (p = 0.772). Conclusion: Our findings in a rather small cohort are concordant with most studies showing no differences or a trend towards better survival after TAE. Other studies found no significant difference regarding recurrence-free survival as well. In conclusion, no significant differences were found between TEG and TAE in surgical treatment of AEG type II.



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Details

Item typeArticle
Journal or Publication TitleDie Chirurgie
Publisher:SPRINGER HEIDELBERG
Open Access Type:DEAL (Springer)
Place of Publication:HEIDELBERG
Date20 August 2022
InstitutionsMedicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Medicine > Institut für Epidemiologie und Präventivmedizin > Tumorzentrum e.V.
Identification Number
ValueType
10.1007/s00104-022-01703-xDOI
KeywordsCANCER; RESECTION; CARDIA; AEG type II; Siewert classification; Cardia; Transhiatal extended gastrectomy; Thoracoabdominal esophagectomy
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-528275
Item ID52827

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