The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression

URN to cite this document:: urn:nbn:de:bvb:355-epub-528382
DOI to cite this document:: 10.5283/epub.52838

Protze, Johanna ; Naas, Stephanie ; Krüger, René ; Stöhr, Christine

; Kraus, Andre ; Grampp, Steffen ; Wiesener, Michael ; Schiffer, Mario

; Hartmann, Arndt ; Wullich, Bernd ; Schödel, Johannes

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 31 Aug 2022 17:17

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Abstract

Evolution of clear cell renal cell carcinoma is guided by dysregulation of hypoxia-inducible transcription factor (HIF) pathways following loss of the von Hippel-Lindau tumor suppressor protein. Renal cell carcinoma (RCC)-associated polymorphisms influence HIF–DNA interactions at enhancers of important oncogenes thereby modulating the risk of developing renal cancer. A strong signal of ...