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Characterization of caspase‐2 inhibitors based on specific sites of caspase‐2‐mediated proteolysis

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Bresinsky, Merlin ; Strasser, Jessica M. ; Hubmann, Alexander ; Vallaster, Bernadette ; McCue, William M. ; Fuller, Jessica ; Singh, Gurpreet ; Nelson, Kathryn M. ; Cuellar, Matthew E. ; Finzel, Barry C. ; Ashe, Karen H. ; Walters, Michael A. ; Pockes, Steffen
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Sep 2022 05:45

This publication is part of the DEAL contract with Wiley.


Since the discovery of the caspase-2 (Casp2)-mediated increment tau314 cleavage product and its associated impact on tauopathies such as Alzheimer's disease, the design of selective Casp2 inhibitors has become a focus in medicinal chemistry research. In the search for new lead structures with respect to Casp2 selectivity and drug-likeness, we have taken an approach by looking more closely at the ...


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