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The endogenous neuropeptide calcitonin gene-related peptide after spontaneous subarachnoid hemorrhage–A potential psychoactive prognostic serum biomarker of pain-associated neuropsychological symptoms

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Bründl, Elisabeth ; Proescholdt, Martin A. ; Störr, Eva-Maria ; Schödel, Petra ; Bele, Sylvia ; Zeman, Florian ; Hohenberger, Christoph ; Kieninger, Martin ; Schmidt, Nils Ole ; Schebesch, Karl-Michael
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Date of publication of this fulltext: 29 Sep 2022 04:40


BackgroundThe pronociceptive neuromediator calcitonin gene-related peptide (CGRP) is associated with pain transmission and modulation. After spontaneous subarachnoid hemorrhage (sSAH), the vasodilatory CGRP is excessively released into cerebrospinal fluid (CSF) and serum and modulates psycho-behavioral function. In CSF, the hypersecretion of CGRP subacutely after good-grade sSAH was significantly ...


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