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In Vivo Comparison of Synthetic Macroporous Filamentous and Sponge-like Skin Substitute Matrices Reveals Morphometric Features of the Foreign Body Reaction According to 3D Biomaterial Designs

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Barsch, Friedrich ; Mamilos, Andreas ; Schmitt, Volker H. ; Babel, Maximilian ; Winter, Lina ; Wagner, Willi ; Winther, Hinrich ; Ottomann, Christian ; Niedermair, Tanja ; Schreml, Stephan ; Hierlemann, Helmut ; Brochhausen, Christoph
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Date of publication of this fulltext: 28 Sep 2022 13:27


Synthetic macroporous biomaterials are widely used in the field of skin tissue engineering to mimic membrane functions of the native dermis. Biomaterial designs can be subclassified with respect to their shape in fibrous designs, namely fibers, meshes or fleeces, respectively, and porous designs, such as sponges and foams. However, synthetic matrices often have limitations regarding unfavorable ...


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