In Vivo Comparison of Synthetic Macroporous Filamentous and Sponge-like Skin Substitute Matrices Reveals Morphometric Features of the Foreign Body Reaction According to 3D Biomaterial Designs

URN to cite this document:

urn:nbn:de:bvb:355-epub-529439 Copy

DOI to cite this document:

10.5283/epub.52943 Copy

Barsch, Friedrich ; Mamilos, Andreas ; Schmitt, Volker H. ; Babel, Maximilian ; Winter, Lina ; Wagner, Willi ; Winther, Hinrich ; Ottomann, Christian ; Niedermair, Tanja ; Schreml, Stephan ; Hierlemann, Helmut ; Brochhausen, Christoph

License: Creative Commons Attribution 4.0 PDF - Published Version (7MB)

Date of publication of this fulltext: 28 Sep 2022 13:27

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Details

Item type:	Article
Open Access Type:	Gold (without APC)
Journal or Publication Title:	Cells
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	11
Number of Issue or Book Chapter:	18
Page Range:	p. 2834
Date:	11 September 2022
Institutions:	Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Pathologie
Identification Number:	Value Type 10.3390/cells11182834 DOI
Keywords:	STEM-CELLS; MYOCARDIAL FIBROSIS; FIBROTIC OVERGROWTH; DERMAL SUBSTITUTE; TISSUE; SCAFFOLDS; REGENERATION; RESPONSES; POLYMER; CHALLENGES; skin substitutes; matrix design; foreign body reaction; histopathology
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	52943

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Abstract

Synthetic macroporous biomaterials are widely used in the field of skin tissue engineering to mimic membrane functions of the native dermis. Biomaterial designs can be subclassified with respect to their shape in fibrous designs, namely fibers, meshes or fleeces, respectively, and porous designs, such as sponges and foams. However, synthetic matrices often have limitations regarding unfavorable ...

Abstract

Synthetic macroporous biomaterials are widely used in the field of skin tissue engineering to mimic membrane functions of the native dermis. Biomaterial designs can be subclassified with respect to their shape in fibrous designs, namely fibers, meshes or fleeces, respectively, and porous designs, such as sponges and foams. However, synthetic matrices often have limitations regarding unfavorable foreign body responses (FBRs). Severe FBRs can result in unfavorable disintegration and rejection of an implant, whereas mild FBRs can lead to an acceptable integration of a biomaterial. In this context, comparative in vivo studies of different three-dimensional (3D) matrix designs are rare. Especially, the differences regarding FBRs between synthetically derived filamentous fleeces and sponge-like constructs are unknown. In the present study, the FBRs on two 3D matrix designs were explored after 25 days of subcutaneous implantation in a porcine model. Cellular reactions were quantified histopathologically to investigate in which way the FBR is influenced by the biomaterial architecture. Our results show that FBR metrics (polymorph-nucleated cells and fibrotic reactions) were significantly affected according to the matrix designs. Our findings contribute to a better understanding of the 3D matrix tissue interactions and can be useful for future developments of synthetically derived skin substitute biomaterials.

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Metadata last modified: 16 Oct 2023 18:12

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