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Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

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Schreiber, Rainer ; Cabrita, Ines ; Kunzelmann, Karl
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Date of publication of this fulltext: 13 Oct 2022 06:36


Background and Aims Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn. The calcium-activated chloride channel TMEM16A and the phospholipid scramblase TMEM16F control intracellular Ca2+ signaling and exocytosis. We analyzed the role of TMEM16A and TMEM16F for Paneth cells secretion. Methods Mice ...


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